Succinic anhydride 丁二酸酐 CAS108-30-5 靶向蛋白降解
Revolutionizing Drug Design: PROTAC Technology</
Meet the PROTAC, a groundbreaking innovation in targeted protein degradation, represented by the chemical compound Succinic Anhydride (CAS 108-30-5). This unique molecule, also known as丁二酸酐, stands out due to its exceptional properties that defy traditional drug requirements.
PROTACs, short for proteolysis-targeting chimeras</, are a class of hybrid molecules that bridge the gap between precision medicine and enzyme-mediated degradation. They consist of three distinct components: a ligand that binds to the target protein, a linker</ that connects the two, and an E3 ligase ligand, forming a molecular triad capable of selectively dismantling targeted proteins in a catalytic-like manner. This remarkable feature allows for effective action with minimal drug doses, eliminating the need for equal molar ratios.
What sets PROTACs apart is their immunogenicity-free structure</, simplicity in synthesis, and ease of cellular penetration. Their versatility has already led to numerous experimental prototypes, each targeting various crucial biological pathways. However, the potential of PROTACs in untapped therapeutic niches</, particularly in the field of drug discovery, remains largely unexplored.
Succinic Anhydride, as a key component in this technology, comes in various forms such as solids, powders, or solutions, with customizable product specifications for research purposes. It is crucial to store it in a refrigerated state at -20°C and maintain its efficacy for up to a year. It's important to note that these compounds are strictly intended for scientific research</, not for human trials.
For those seeking compatible reagents</, some examples include:
- M-PEG7-Br (CAS 104518-25-4) – Methy-Seven-聚乙二醇-溴代
- PEG12-Tos (CAS 1050500-41-8) – 十二乙二醇单对甲苯磺酸酯
- M-PEG2-4-nitrophenyl carbonate
- Boc-NH-PEG8-CH2CH2NH2 (CAS 1052207-59-6) – 叔丁基八聚乙二醇氨基
- N3-PEG3-CH2CH2COOH
Stay ahead in the realm of cutting-edge research with瑞禧WFF.2023.9, where every discovery brings us closer to personalized medicine.
扩展阅读：www.sony.com.cn ... sci hub ... abscisic acid ... saint laurent官网 ... succinic anhydride ... anhydrous sodium ... sci免费入口 ... oxalic acid ... science advances ...
