主要组织相容性复合物 MHC 的本质是不是基因？ MHC上全是显性基因吗？
\u4e2a\u4f53\u6700\u591a\u6709\u591a\u5c11\u79cdHLA-DR\u57fa\u56e0\uff1f\u6216\u8005\u8bf4\uff0c\u5355\u4e2a\u7ec6\u80de\u8868\u8fbe\u591a\u5c11\u79cdMHC II\uff1fHLA-DR \u7531\u4e00\u4e2aalpha\u94fe\uff0c\u4e00\u4e2a\u03b2\u94fe\u7ec4\u6210\u3002Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted.
\u6211\u5728wiki\u4e0a\u770b\u5230\u7684\u548c\u4f60\u770b\u5230\u7684\u4e0d\u4e00\u6837\u554a\uff1a
The genetics of HLA-DR is complex. HLA-DR is encoded by several loci and several 'genes' of different function at each locus. The DR \u03b1-chain is encoded by the HLA-DRA locus. Unlike the other DR loci functional variation in mature DRA gene products is absent. (Note: see table Number of Variant Alleles HLA-DR Loci- reduces the potential functional combinations from ~1400 to ~400 (table is not exact because new alleles are continually being added not all new alleles are functional variants of the mature subunits)).
The DR \u03b2-chain[2] is encoded by 4 loci, however no more than 3 functional loci are present in a single individual, and no more than two on a single chromosome. Sometimes an individual may only possess 2 copies of the same locus, DRB1*. The HLA-DRB1 locus is ubiquitous and encodes a very large number of functionally variable gene products (HLA-DR1 to HLA-DR17). The HLA-DRB3 locus encodes the HLA-DR52 specificity, is moderately variable and is variably associated with certain HLA-DRB1 types. The HLA-DRB4 locus encodes the HLA-DR53 specificity, has some variation, and is associated with certain HLA-DRB1 types. The HLA-DRB5 locus encodes the HLA-DR51 specificity, which is typically invariable, and is linked to the HLA-DR2 types.
\u5e0c\u671b\u8fd9\u4e2a\u80fd\u89e3\u4f60\u7684\u7b54\u6848\u3002
MHC\u662f\u4e00\u7c07\u4f4d\u4e8e\u4eba\u7b2c6\u53f7\u67d3\u8272\u4f53\u6216\u5c0f\u9f20\u7b2c17\u53f7\u67d3\u8272\u4f53\u4e0a\u7684\u57fa\u56e0\u7fa4\u3002\u5b83\u4eec\u7f16\u7801\u4e00\u7cfb\u5217\u79f0\u4e4b\u4e3aMHC\u5206\u5b50\u7684\u819c\u7cd6\u86cb\u767d\u3002
MHC I\u7c7b\u5206\u5b50\u5c06\u7ec6\u80de\u8d28\u4e2d\u4ea7\u751f\u7684\u80bd\u5448\u9012\u7ed9CD8 T\u7ec6\u80de\uff0c\u800cMHC II\u7c7b\u5206\u5b50\u5c06\u80de\u5185\u5c0f\u56ca\u6ce1\u4e2d\u964d\u89e3\u7684\u80bd\u5448\u9012\u7ed9CD4 T\u7ec6\u80de\u3002
MHC\u8fd8\u7f16\u7801\u53c2\u4e0e\u6297\u539f\u52a0\u5de5\u548c\u5bbf\u4e3b\u9632\u5fa1\u5176\u4ed6\u65b9\u9762\u7684\u86cb\u767d\u8d28\u3002MHC\u662f\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u6700\u5177\u591a\u6001\u6027\u7684\u57fa\u56e0\u7c07\uff0c\u5728\u51e0\u4e2a\u4e0d\u540c\u7684\u57fa\u56e0\u5ea7\u4e0a\u62e5\u6709\u5927\u91cf\u7684\u7b49\u4f4d\u57fa\u56e0\u3002\u7531\u4e8e\u8fd9\u79cd\u591a\u6001\u6027\u901a\u5e38\u662f\u6709\u6297\u4f53\u6216\u7279\u5f02\u6027T\u7ec6\u80de\u8fdb\u884c\u68c0\u6d4b\u7684\uff0cMHC\u5206\u5b50\u4e5f\u5e38\u88ab\u79f0\u4e3a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\u3002
MHC\u9650\u5236\u6027\u3002\u4e00\u4e2a\u7279\u5b9a\u7684T\u7ec6\u80de\u53ea\u6709\u5f53\u5b83\u4e0e\u7279\u6b8a\u7684MHC\u5206\u5b50\u7ed3\u5408\u65f6\u5019\u624d\u80fd\u8bc6\u522b\u5176\u4e0a\u7684\u6297\u539f\u80bd\uff0c\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cT\u7ec6\u80de\u53ea\u6709\u5728\u81ea\u8eabMHC\u5206\u5b50\u5b58\u5728\u7684\u524d\u63d0\u4e0b\uff0c\u624d\u80fd\u8bc6\u522b\u4e0e\u81ea\u8eabMHC\u5206\u5b50\u7ed3\u5408\u7684\u591a\u80bd\u5e76\u6d3b\u5316\u3002
HLA -\u2160\u7c7b\u5206\u5b50\u4e3b\u8981\u5206\u5e03\u4e8e\u673a\u4f53\u6240\u6709\u6709\u6838\u7ec6\u80de\u8868\u9762\uff0c\u4ee5\u6dcb\u5df4\u7ec6\u80de\u2160\u7c7b\u5206\u5b50\u7684\u5bc6\u5ea6\u6700\u5927\uff0c\u5176\u6b21\u4e3a\u80be.\u809d\u53ca\u5fc3\u810f\uff0c\u5bc6\u5ea6\u6700\u4f4e\u7684\u4e3a\u808c\u8089\u548c\u795e\u7ecf\u7ec4\u7ec7\u3002\u8840\u6e05.\u521d\u4e73\u53ca\u5c3f\u6db2\u4e2d\u8fd8\u5b58\u5728\u53ef\u6eb6\u6027\u7684\u2160\u7c7b\u5206\u5b50\u3002
HLA-\u2161\u7c7b\u5206\u5b50\u4ec5\u8868\u8fbe\u4e8e\u4e13\u804c\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08B\u7ec6\u80de\uff0c\u5de8\u566c\u7ec6\u80de\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\uff09\u4ee5\u53ca\u6d3b\u5316\u7684T\u7ec6\u80de\u548c\u80f8\u817a\u4e0a\u76ae\u7ec6\u80de\u7b49\u8868\u9762\u3002
摘自《医学免疫学》
这个好像是比较复杂的生物问题啊、、
扩展阅读：正常怀孕hcg参考值 ... 刚受孕7-10天hcg数值 ... 孕1-40周hcg值对照表 ... 免疫组化结果一览表 ... 一般刚着床的hcg是多少 ... 游离βhcg对照表 ... 特异hcg测定多少是怀孕 ... 生化妊娠hcg最高值 ... 过硫酸氢钾的使用禁忌 ...
