发作性睡病的形成主要有哪几种原因？ 引起发作性睡病的原因有哪些呢？
\u53d1\u4f5c\u6027\u7761\u75c5\u662f\u54ea\u51e0\u79cd\u5bfc\u81f4\u7684\uff1f\u53d1\u4f5c\u6027\u7761\u75c5\uff08narcolepsy\uff09\u662f\u4e00\u79cd\u539f\u56e0\u4e0d\u660e\u7684\u6162\u6027\u7761\u7720\u969c\u788d\uff0c\u4e34\u5e8a\u4e0a\u4ee5\u4e0d\u53ef\u6297\u62d2\u7684\u77ed\u671f\u7761\u7720\u53d1\u4f5c\u4e3a\u7279\u70b9\uff0c\u591a\u4e8e\u513f\u7ae5\u6216\u9752\u5e74\u671f\u8d77\u75c5\u3002\u5f80\u5f80\u4f34\u6709\u731d\u5012\u53d1\u4f5c\u3001\u7761\u7720\u762b\u75ea\u75c7\u3001\u7761\u7720\u5e7b\u89c9\u7b49\u5176\u4ed6\u75c7\u72b6\uff0c\u5408\u79f0\u4e3a\u53d1\u4f5c\u6027\u7761\u75c5\u56db\u8054\u75c7\u3002
\u53d1\u75c5\u673a\u5236\u5c1a\u672a\u6e05\u695a\uff0c\u53ef\u80fd\u4e0e\u8111\u5e72\u7f51\u72b6\u7ed3\u6784\u4e0a\u884c\u6fc0\u6d3b\u7cfb\u7edf\u529f\u80fd\u964d\u4f4e\u6216\u6865\u8111\u5c3e\u4fa7\u7f51\u72b6\u6838\u529f\u80fd\u4ea2\u8fdb\u6709\u5173\u3002
\u75c5\u56e0\u76ee\u524d\u672a\u660e\uff0c\u4f46\u53ef\u53d1\u73b0\u6b64\u75c5\u8ddf\u57fa\u56e0\u3001\u73af\u5883\u56e0\u7d20\u53ca\u67d0\u4e9b\u4e2d\u67a2\u795e\u7ecf\u75be\u75c5\u6709\u5173\u3002\u5bf9\u53ef\u80fd\u8bf1\u53d1\u53d1\u4f5c\u6027\u7761\u75c5\u7684\u73af\u5883\u56e0\u7d20\u73b0\u5728\u77e5\u4e4b\u751a\u5c11\uff0c\u6587\u732e\u62a5\u9053\u6709\u5305\u62ec\u5934\u90e8\u5916\u4f24\u3001\u7761\u7720\u4e60\u60ef\u6539\u53d8\u3001\u7cbe\u795e\u523a\u6fc0\u53ca\u75c5\u6bd2\u611f\u67d3\u7b49\u3002\u800c\u53d1\u4f5c\u6027\u7761\u75c5\u4e0e\u9057\u4f20\u57fa\u56e0\u7684\u5173\u7cfb\u662f\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u5927\u7ea68%-10%\u7684\u53d1\u4f5c\u6027\u7761\u75c5\u60a3\u8005\u5177\u6709\u5bb6\u65cf\u53f2\uff0c\u60a3\u8005\u76f4\u7cfb\u4eb2\u5c5e\u60a3\u75c5\u7684\u51e0\u7387\u4e3a\u5bf9\u7167\u7ec4\u768410-40\u500d\uff1b25%-31%\u7684\u5355\u5375\u53cc\u751f\u5b50\u5171\u60a3\u53d1\u4f5c\u6027\u7761\u75c5\uff0c\u63d0\u793a\u9057\u4f20\u56e0\u7d20\u5728\u5176\u8d77\u75c5\u4e2d\u6709\u91cd\u8981\u4f5c\u7528\u3002HLA\u7b49\u4f4d\u57fa\u56e0DQB1*0602\u5728\u53d1\u4f5c\u6027\u7761\u75c5\u60a3\u8005\u4e2d\u6709\u5f88\u9ad8\u7684\u9633\u6027\u7387\uff0c\u8fbe88%-100%\u3002
\u897f\u836f\u6cbb\u7597
\uff08\u4e00\uff09\u8fc7\u5ea6\u55dc\u7761\u7684\u6cbb\u7597
1\u3001\u4e2d\u67a2\u5174\u594b\u5242\uff1a\u5bf9\u7f51\u72b6\u6fc0\u6d3b\u7cfb\u7edf\u4ea7\u751f\u6fc0\u6d3b\u4f5c\u7528\uff0c\u53d1\u6325\u5f88\u5f3a\u7684\u5174\u594b\u6548\u679c\uff0e\u662f\u6cbb\u7597\u7761\u7720\u53d1\u4f5c\u7684\u6709\u6548\u836f\u7269\u3002
2\uff0e\u5176\u4ed6\u836f\u7269\uff1a\u56e0\u53d1\u4f5c\u6027\u7761\u75c5\u4e0eDA \u7684\u4ee3\u8c22\u6709\u5173\uff0c\u53ef\u901a\u8fc7\u63d0\u9ad8\u7a81\u89e6\u524d\u7684DA \u6c34\u5e73\u6765\u6cbb\u7597\u53d1\u4f5c\u6027\u7761\u75c5\u3002
\uff08\u4e8c\uff09\u731d\u5012\u7684\u6cbb\u7597
1 \uff0e\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u836f\u7269\uff1a\u53ef\u9006\u8f6c\u731d\u5012\u53d1\u4f5c\uff0c\u5982\u5730\u6614\u5e15\u660e\u3001\u7ef4\u6d1b\u6c99\u79e6\u548c\u6587\u62c9\u6cd5\u8f9b\u7b49\uff0c\u5747\u80fd\u6709\u6548\u5730\u5bf9\u6297\u731d\u5012\u3002
2 \uff0e\u4e09\u73af\u7c7b\u6297\u6291\u90c1\u836f\uff1a\u80fd\u589e\u52a0\u8840\u6db2\u4e2dNE \u7b49\u5355\u80fa\u7c7b\u7684\u542b\u91cf\uff0c\u662f\u5e38\u7528\u7684\u6297\u731d\u5012\u836f\u7269\u3002
3\uff0e\u7f9f\u4e01\u9178\u94a0\uff1a\u662fGABA \u7684\u884d\u751f\u7269\uff0c\u8fbe\u5cf0\u65f6\u95f4\u4e3a40 \u5206\u949f\uff0c\u534a\u8870\u671f\u4e3a53 \u5206\u949f\uff0c\u7528\u836f1\u5468\u540e\u731d\u5012\u53d1\u4f5c\u5373\u51cf\u5c1153 %\uff0c 4 \u5468\u540e\u51cf\u5c1169 % \uff0c\u5bf9\u65e5\u95f4\u601d\u7761\u3001\u7761\u762b\u75c7\u548c\u4eba\u7761\u524d\u5e7b\u89c9\u7b49\u75c7\u72b6\u4e5f\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u6539\u5584\u3002
\uff08\u4e09\uff09\u5931\u7720\u7684\u6cbb\u7597
\u60a3\u8005\u5982\u5728\u767d\u5929\u4f7f\u7528\u5174\u594b\u5242\u540e\uff0c\u591c\u95f4\u53ef\u51fa\u73b0\u5931\u7720\u6216\u7761\u4e2d\u4e0d\u5b81\u7b49\uff0c\u6b64\u65f6\u5b9c\u9009\u7528\u77ed\u534a\u8870\u671f\u50ac\u7720\u836f\uff0c\u5982\u5511\u5421\u5766\u7b49\u7761\u524d\u53e3\u670d\uff0c\u5c3d\u91cf\u907f\u514d\u7ed9\u4e88\u534a\u8870\u671f\u957f\u7684\u50ac\u7720\u836f\uff0c\u4ee5\u9632\u767d\u5929\u7761\u610f\u52a0\u91cd\u3002
\u4e2d\u533b\u4e2d\u836f\u6cbb\u7597
\uff08\u4e00\uff09 \u5fc3\u813e\u4e24\u865a
1. \u75c7\u72b6 \u55dc\u7761\uff0c\u7761\u524d\u591a\u773c\u82b1\u5e7b\u5f71\uff0c\u795e\u75b2\u5fc3\u60b8\uff0c\u9762\u8272\u4e0d\u534e\uff0c\u82d4\u8584\u767d\uff0c\u8109\u7ec6\u5f31\u3002
2 \uff0e\u6cbb\u6cd5 \u8865\u76ca\u5fc3\u813e\u3002
3 \uff0e\u65b9\u836f \u5f52\u813e\u6c64\u52a0\u51cf\u3002
\u82e5\u8179\u80c0\u3001\u8118\u95f7\u3001\u7eb3\u5dee\u3001\u820c\u82d4\u817b\u8005\uff0c\u52a0\u832f\u82d3\u3001\u85ff\u9999\u3001\u539a\u6734\u4ee5\u82b3\u9999\u5316\u6e7f\uff0c\u5065\u813e\u884c\u6c14\uff1b\u7761\u524d\u773c\u82b1\u5e7b\u5f71\u8f83\u591a\u56e0\u5fc3\u9634\u4e0d\u8db3\u8005\uff0c\u52a0\u9ea6\u51ac\u3001\u7389\u7af9\u3001\u5317\u6c99\u53c2\u3002
\uff08\u4e8c\uff09\u813e\u6c14\u865a\u5f31
1 \uff0e\u75c7\u72b6 \u6574\u65e5\u660f\u660f\u6b32\u7761\uff0c\u9762\u8272\u840e\u9ec4\uff0c\u795e\u5026\u80a2\u6020\uff0c\u5931\u7720\u591a\u68a6\uff0c\u5fc3\u60b8\u6c14\u77ed\uff0c\u5065\u5fd8\u6613\u60ca\uff0c\u820c\u8d28\u6de1\uff0c\u820c\u82d4\u8584\u767d\uff0c\u8109\u7ec6\u5f31\u3002
2 \uff0e\u6cbb\u6cd5 \u8865\u76ca\u6c14\u8840\uff0c\u8363\u8111\u9192\u795e\u3002
3 \uff0e\u65b9\u836f \u517b\u5fc3\u6c64\u52a0\u51cf
\u5982\u6c34\u996e\u5185\u505c\uff0c\u5fc3\u60b8\u6014\u5fe1\u8005\uff0c\u52a0\u732a\u82d3\u3001\u69df\u6994\u3001\u6cfd\u6cfb\uff1b\u6574\u65e5\u660f\u7761\u4e0d\u9192\u8005\uff0c\u52a0\u82cf\u5408\u9999\u3001\u77f3\u83d6\u84b2\u3001\u76ca\u667a\u4ec1\u4ee5\u5f00\u7a8d\u9192\u795e\u3002
\uff08\u4e09\uff09\u80be\u9633\u4e0d\u8db3
1 \uff0e\u75c7\u72b6 \u55dc\u7761\u53d1\u4f5c\uff0c\u6216\u660f\u660f\u6b32\u5bd0\uff0c\u8170\u819d\u9178\u8f6f\uff0c\u754f\u5bd2\u80a2\u51b7\uff0c\u9633\u75ff\uff0c\u5c0f\u4fbf\u6e05\u957f\uff0c\u591c\u5c3f\u9891\u6570\uff0c\u820c\u8d28\u6de1\uff0c\u820c\u82d4\u8584\u767d\uff0c\u8109\u6c89\u7ec6\u5fae\u5f31\u3002
2 \uff0e\u6cbb\u6cd5 \u6e29\u8865\u80be\u9633\u3002
3 \uff0e\u65b9\u836f \u53f3\u5f52\u996e\u52a0\u51cf\u3002
\u82e5\u6c14\u865a\u8840\u8131\u7b49\uff0c\u52a0\u4eba\u53c2\u91cd\u7528\u5e76\u52a0\u767d\u672f\u3001\u9ec4\u82aa\u3002
\uff08\u56db\uff09\u9ad3\u6d77\u4e0d\u8db3
1 \uff0e\u75c7\u72b6 \u6020\u60f0\u55dc\u7761\uff0c\u8170\u819d\u9178\u8f6f\uff0c\u5934\u660f\u8111\u9e23\uff0c\u6216\u8033\u9e23\u8033\u804b\uff0c\u795e\u60c5\u5446\u6ede\uff0c\u601d\u7ef4\u8fdf\u949d\uff0c\u7cbe\u795e\u4e0d\u6d4e\uff0c\u8bb0\u5fc6\u529b\u51cf\u9000\uff0c\u820c\u8d28\u6de1\u7ea2\uff0c\u820c\u82d4\u8584\u767d\uff0c\u8109\u7ec6\u5f31\u6216\u7ec6\u6570\u3002
2 \uff0e\u6cbb\u6cd5 \u586b\u7cbe\u8865\u9ad3\uff0c\u5065\u8111\u5229\u7a8d\u3002
3 \uff0e\u65b9\u836f \u5de6\u5f52\u4e38\u52a0\u51cf\u3002
\u9057\u7cbe\uff0c\u68a6\u4ea4\u8005\uff0c\u52a0\u751f\u7261\u86ce\u3001\u91d1\u6a31\u5b50\u3001\u82a1\u5b9e\u3001\u83b2\u987b\u56fa\u80be\u6da9\u7cbe\uff1b\u6f6e\u70ed\uff0c\u76d7\u6c57\uff0c\u53e3\u5e72\u8005\u53bb\u5c71\u8331\u8438\u3001\u9e7f\u7532\u80f6\uff0c\u52a0\u77e5\u6bcd\u3001\u9ec4\u67cf\u6ecb\u9634\u6cfb\u706b\u3002
\uff08\u4e94\uff09\u5fc3\u9633\u4e0d\u8db3
1 \uff0e\u75c7\u72b6 \u55dc\u5367\u5026\u6020\uff0c\u7cbe\u795e\u840e\u9761\uff0c\u754f\u5bd2\u80a2\u51b7\uff0c\u9762\u8272\u6644\u767d\uff0c\u820c\u8d28\u6de1\uff0c\u82d4\u8584\u767d\uff0c\u8109\u6c89\u7ec6\u3002
2 \uff0e\u6cbb\u6cd5 \u6e29\u8865\u5fc3\u9633\uff0c\u8865\u76ca\u5fc3\u6c14\u3002
3 \uff0e\u65b9\u836f \u6842\u679d\u7518\u8349\u6c64\u5408\u4eba\u53c2\u76ca\u6c14\u6c64\u52a0\u51cf\u3002
\u754f\u5bd2\u80a2\u51b7\u751a\u8005\uff0c\u53bb\u6842\u679d\u52a0\u8089\u6842\u3001\u5e72\u59dc\u4ee5\u8865\u706b\u52a9\u9633\uff0c\u6e29\u901a\u7ecf\u8109\uff1b\u9762\u8272\u82cd\u767d\u8840\u865a\u751a\u8005\uff0c\u52a0\u963f\u80f6\u3001\u719f\u5730\u3001\u67b8\u675e\u5b50\u3001\u4f55\u9996\u4e4c\u8865\u8840\u3002
\uff08\u516d\uff09\u80c6\u70ed\u75f0\u963b
1 \uff0e\u75c7\u72b6 \u660f\u56f0\u55dc\u7761\uff0c \u5934\u6655\u76ee\u7729\uff0c\u53e3\u82e6\u53e3\u5e72\uff0c\u5455\u6076\uff0c\u80f8\u80c1\u6ee1\u95f7\uff0c\u820c\u7ea2\u82d4\u9ec4\uff0c\u8109\u5f26\u6570\u3002
2 \uff0e\u6cbb\u6cd5 \u6e05\u80c6\u5316\u75f0\u3002
3 \uff0e\u65b9\u836f \u84bf\u82a9\u6e05\u80c6\u6c64\u52a0\u51cf\u3002
\u56e0\u75f0\u6d4a\u5185\u963b\uff0c\u6c14\u9006\u4e0d\u964d\u89c1\u5fc3\u4e0b\u75de\u786c\u3001\u566b\u6c14\u4e0d\u9664\u8005\uff0c\u52a0\u65cb\u8986\u4ee3\u8d6d\u6c64\u4ee5\u76ca\u6c14\u548c\u80c3\uff0c\u5316\u75f0\u964d\u6c14\uff1b\u82e5\u660f\u7761\u4e0d\u9192\u8005\u53ef\u52a0\u5b89\u5bab\u725b\u9ec4\u4e38\u9192\u8111\u5f00\u7a8d\u3002
\uff08\u4e03\uff09\u6691\u6e7f\u4f24\u6c14
1 \uff0e\u75c7\u72b6 \u660f\u56f0\u55dc\u7761\uff0c\u56db\u80a2\u56f0\u5026\uff0c\u7eb3\u5446\u80f8\u6ee1\uff0c\u8eab\u70ed\u81ea\u6c57\uff0c\u5934\u75db\uff0c\u53e3\u6e34\uff0c\u5927\u4fbf\u6e8f\u6cc4\uff0c\u5c0f\u4fbf\u77ed\u8d64\uff0c\u820c\u82d4\u817b\uff0c\u8109\u865a\u3002
2 \uff0e\u6cbb\u6cd5 \u6e05\u6691\u76ca\u6c14\u3002
3 \uff0e\u65b9\u836f \u6e05\u6691\u76ca\u6c14\u6c64\u52a0\u51cf\u3002
\u82e5\u6691\u70ed\u8f83\u751a\u8005\uff0c\u52a0\u77f3\u818f\uff1b\u6e7f\u6d4a\u751a\u8005\u89c1\u820c\u82d4\u767d\u817b\uff0c\u53bb\u9ea6\u51ac\u3001\u77e5\u6bcd\uff0c\u52a0\u5e7f\u85ff\u9999\u3001\u8349\u8c46\u5bc7\u3002
\uff08\u516b\uff09\u813e\u6e7f\u809d\u90c1
1 \uff0e\u75c7\u72b6 \u55dc\u7761\u9891\u4f5c\uff0c\u5934\u8111\u660f\u8499\uff0c\u7cbe\u795e\u59d4\u987f\uff0c\u80a2\u4f53\u6c89\u91cd\uff0c\u5026\u6020\u4e4f\u529b\uff0c\u6708\u7ecf\u91cf\u591a\uff0c\u8272\u7d2b\u6709\u5757\uff0c\u8170\u91cd\u75db\uff0c\u767d\u5e26\u591a\uff0c\u54b3\u5410\u6d4a\u75f0\uff0c\u5934\u6655\u5934\u75db\uff0c\u6216\u80c3\u8118\u5608\u6742\uff0c\u795e\u75b2\u9762\u6666\uff0c\u8bb0\u5fc6\u529b\u5dee\uff0c\u4fbf\u5e72\u6eb2\u9ec4\uff0c\u820c\u6de1\u7ea2\uff0c\u82d4\u767d\u539a\u800c\u817b\uff0c\u8109\u6c89\u5f26\u3002
2 \uff0e\u6cbb\u6cd5 \u5065\u813e\u758f\u809d\uff0c\u9664\u6e7f\u9192\u8111\u3002
3 \uff0e\u65b9\u836f \u5b8c\u5e26\u6c64\u52a0\u51cf\u3002
\u767d\u5e26\u591a\u8005\u52a0\u4e4c\u8d3c\u9aa8\u3001\u82a1\u5b9e\u3001\u7145\u7261\u86ce\u6536\u6da9\u6b62\u5e26\uff1b\u54b3\u5410\u75f0\u6d4a\u8f83\u591a\u8005\u52a0\u6cd5\u534a\u590f\u3001\u5929\u5357\u661f\uff1b\u5934\u6655\u3001\u5934\u75db\u91cd\u8005\u52a0\u83ca\u82b1\u3001\u5ddd\u828e\u3001\u5929\u9ebb\u7b49\u3002
\uff08\u4e5d\uff09\u6e7f\u6d4a\u56f0\u813e
1 \uff0e\u75c7\u72b6 \u55dc\u7761\u9891\u4f5c\uff0c\u5934\u8111\u660f\u8499\uff0c\u7cbe\u795e\u59d4\u987f\uff1b\u80a2\u4f53\u6c89\u91cd\uff0c\u5026\u6020\u4e4f\u529b\uff0c\u80f8\u95f7\u75de\u6ee1\uff0c\u53e3\u817b\u7eb3\u5446\uff0c\u820c\u8d28\u6de1\uff0c\u820c\u82d4\u767d\u539a\u800c\u817b\uff0c\u8109\u6fe1\u7f13\u6216\u6ed1\u3002
2 \uff0e\u6cbb\u6cd5 \u5065\u813e\u795b\u6e7f\uff0c\u5f00\u7a8d\u9192\u795e\u3002
3 \uff0e\u65b9\u836f \u534a\u590f\u767d\u672f\u5929\u9ebb\u6c64\u52a0\u51cf\u3002
\u82e5\u6e7f\u75f0\u504f\u76db\uff0c\u820c\u82d4\u767d\u6ed1\u8005\uff0c\u52a0\u6cfd\u6cfb\u3001\u6842\u679d\u5229\u6e7f\u5316\u996e\uff1b\u82e5\u809d\u9633\u504f\u4ea2\u8005\uff0c\u52a0\u94a9\u85e4\u3001\u73cd\u73e0\u6bcd\u3001\u4ee3\u8d6d\u77f3\u606f\u98ce\u6f5c\u9633\u3002
\uff08\u5341\uff09\u7600\u8840\u963b\u6ede
1 \uff0e\u75c7\u72b6 \u55dc\u7761\u53d1\u4f5c\uff0c\u8fc1\u5ef6\u65e5\u4e45\uff0c\u795e\u75b2\u4e4f\u529b\uff0c\u5934\u8111\u660f\u6c89\uff0c\u8bb0\u5fc6\u529b\u51cf\u9000\uff0c\u65f6\u6709\u5934\u75db\uff0c\u5931\u7720\u591a\u68a6\uff0c\u820c\u8d28\u7d2b\u6697\uff0c\u5e38\u6709\u7600\u70b9\u6216\u7600\u6591\uff0c\u8109\u7ec6\u6da9\u65e0\u529b\u3002
2 \uff0e\u6cbb\u6cd5 \u884c\u6c14\u6d3b\u8840\uff0c\u5f00\u7a8d\u5229\u8111\u3002
3 \uff0e\u65b9\u836f \u901a\u7a8d\u6d3b\u8840\u6c64\u52a0\u51cf\u3002
\u82e5\u5934\u75db\u751a\u8005\u52a0\u845b\u6839\u3001\u5ef6\u80e1\u7d22\u7b49\uff1b\u5939\u7600\u8840\u62bd\u6410\u8005\u52a0\u50f5\u8695\u3001\u5168\u874e\u3001\u8708\u86a3\u3002
\u4e2d\u533b\u9488\u7078\u6cbb\u7597
1 \uff0e\u4f53\u9488
( 1 )\u65b9\u6cd51
\u4e3b\u7a74\uff1a\u9f3b\u4ea4\u3002
\u914d\u7a74\uff1a\u795e\u95e8\u3001\u4e09\u9634\u4ea4\u3001\u592a\u51b2\u3002
( 2 )\u65b9\u6cd52
\u4e3b\u7a74\uff1a\u7533\u8109\u3001\u7167\u6d77\u3002
\u914d\u7a74\uff1a\u767e\u4f1a\u3001\u4e09\u9634\u4ea4\u3002
2 \uff0e\u5934\u9488
\u4e3b\u7a74\uff1a\u56fd\u6807\u5934\u9488\u9876\u4e2d\u7ebf\u3001\u989d\u4e2d\u7ebf\u3002
\u914d\u7a74\uff1a\u6e7f\u6d4a\u56f0\u813e\u8005\u52a0\u989d\u65c1\u4e8c\u7ebf\uff08\u53cc\uff09\u3001\u989d\u9876\u5e26\uff1b\u5fc3\u813e\u4e24\u865a\u8005\uff0c\u52a0\u989d\u65c1\u4e00\u7ebf\uff08\u53f3\uff09\u3001\u989d\u65c1\u4e8c\u7ebf\uff1b\u80be\u9633\u4e0d\u8db3\u8005\uff0c\u52a0\u989d\u65c1\u4e09\u7ebf\uff08\u53cc\uff09\u3001\u6795\u4e0a\u6b63\u4e2d\u7ebf\u3001\u6795\u4e0a\u65c1\u7ebf\uff08\u53cc\uff09\uff1b\u9ad3\u6d77\u4e0d\u8db3\u8005\uff0c\u52a0\u989d\u65c1\u4e09\u7ebf\uff08\u53cc\uff09\u3002
3 \uff0e\u6e29\u9488\u7078
\u53d6\u7a74\uff1a\u901a\u91cc\u3001\u5927\u949f\u3001\u5fc3\u4fde\u3001\u813e\u4fde\u3002
4 \uff0e\u8033\u7a74\u8d34\u538b \u53d6\u795e\u95e8\u3001\u8111\u5e72\u3001\u76ae\u8d28\u4e0b\u3001\u6795\u5c0f\u795e\u7ecf\u70b9\u3001\u809d\u3001\u813e\u3001\u5fc3\u7a74\u3002
\u63a8\u62ff\u6309\u6469\u6cbb\u7597
\u91c7\u7528\u5faa\u7ecf\u63a8\u8fd0\u677e\u89e3\u7597\u6cd5\u3002\u4ee4\u60a3\u8005\u53d6\u4fef\u5367\u4f4d\uff0c\u8eab\u4f53\u653e\u677e\uff0c\u5e73\u7a33\u547c\u5438\u3002\u672f\u8005\u4f4d\u4e8e\u60a3\u8005\u53f3\u4fa7\uff0c\u7528\u53cc\u624b\u7684\u62c7\u3001\u98df\u3001\u4e2d\u548c\u65e0\u540d\u6307\u5728\u60a3\u8005\u4f53\u8868\u64cd\u4f5c\u3002
\u5fc3\u7406\u6cbb\u7597
1 \uff0e\u53d1\u4f5c\u6027\u7761\u75c5\u90e8\u5206\u60a3\u8005\u51fa\u73b0\u53cd\u5e94\u6027\u6291\u90c1\u75c7\u72b6\uff0c\u5e94\u7ed9\u60a3\u8005\u4ee5\u5fc3\u7406\u652f\u6301\uff0c\u589e\u5f3a\u5176\u6cbb\u7597\u4fe1\u5fc3\uff0c\u5e76\u53d6\u5f97\u5bb6\u4eba\u3001\u540c\u4e8b\u7684\u7406\u89e3\u4e0e\u652f\u6301\u3002
2 \uff0e\u884c\u4e3a\u6cbb\u7597\uff1a\u6539\u53d8\u539f\u6709\u7684\u751f\u6d3b\u65b9\u5f0f\u3002
3 \uff0e\u5408\u7406\u5b89\u6392\u4f5c\u606f\u65f6\u95f4\uff0c\u5f3a\u8c03\u6709\u89c4\u5f8b\u7684\u5de5\u4f5c\u548c\u4f11\u606f\uff0c\u5c3d\u91cf\u4fdd\u8bc1\u591c\u95f4\u83b7\u5f97\u5145\u8db3\u7684\u7761\u7720\u3002\u907f\u514d\u60c5\u7eea\u6fc0\u52a8\u548c\u8fc7\u5ea6\u7d27\u5f20\u3002\u767d\u5929\u52a0\u5f3a\u4f53\u529b\u6d3b\u52a8\u4ee5\u6539\u5584\u767d\u5929\u8fc7\u5ea6\u55dc\u7761\u3002
\u53d1\u4f5c\u6027\u7761\u75c5\uff08narcolepsy\uff09\u662f\u4e00\u79cd\u539f\u56e0\u4e0d\u660e\u7684\u6162\u6027\u7761\u7720\u969c\u788d\uff0c\u4e34\u5e8a\u4e0a\u4ee5\u4e0d\u53ef\u6297\u62d2\u7684\u77ed\u671f\u7761\u7720\u53d1\u4f5c\u4e3a\u7279\u70b9\uff0c\u591a\u4e8e\u513f\u7ae5\u6216\u9752\u5e74\u671f\u8d77\u75c5\u3002\u5f80\u5f80\u4f34\u6709\u731d\u5012\u53d1\u4f5c\u3001\u7761\u7720\u762b\u75ea\u75c7\u3001\u7761\u7720\u5e7b\u89c9\u7b49\u5176\u4ed6\u75c7\u72b6\uff0c\u5408\u79f0\u4e3a\u53d1\u4f5c\u6027\u7761\u75c5\u56db\u8054\u75c7\u3002\u53d1\u4f5c\u6027\u7761\u75c5\u4e00\u8bcd\uff0c\u7531Gelineau\u4e8e1880\u5e74\u9996\u521b\uff0c\u56e0\u6b64\u672c\u75c5\u53c8\u79f0Gelineau\u7efc\u5408\u5f81
\u53d1\u75c5\u673a\u5236\u5c1a\u672a\u6e05\u695a\uff0c\u53ef\u80fd\u4e0e\u8111\u5e72\u7f51\u72b6\u7ed3\u6784\u4e0a\u884c\u6fc0\u6d3b\u7cfb\u7edf\u529f\u80fd\u964d\u4f4e\u6216\u6865\u8111\u5c3e\u4fa7\u7f51\u72b6\u6838\u529f\u80fd\u4ea2\u8fdb\u6709\u5173\u3002
\u75c5\u56e0\u76ee\u524d\u672a\u660e\uff0c\u4f46\u53ef\u53d1\u73b0\u6b64\u75c5\u8ddf\u57fa\u56e0\u3001\u73af\u5883\u56e0\u7d20\u53ca\u67d0\u4e9b\u4e2d\u67a2\u795e\u7ecf\u75be\u75c5\u6709\u5173\u3002\u5bf9\u53ef\u80fd\u8bf1\u53d1\u53d1\u4f5c\u6027\u7761\u75c5\u7684\u73af\u5883\u56e0\u7d20\u73b0\u5728\u77e5\u4e4b\u751a\u5c11\uff0c\u6587\u732e\u62a5\u9053\u6709\u5305\u62ec\u5934\u90e8\u5916\u4f24\u3001\u7761\u7720\u4e60\u60ef\u6539\u53d8\u3001\u7cbe\u795e\u523a\u6fc0\u53ca\u75c5\u6bd2\u611f\u67d3\u7b49\u3002\u800c\u53d1\u4f5c\u6027\u7761\u75c5\u4e0e\u9057\u4f20\u57fa\u56e0\u7684\u5173\u7cfb\u662f\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u5927\u7ea68%-10%\u7684\u53d1\u4f5c\u6027\u7761\u75c5\u60a3\u8005\u5177\u6709\u5bb6\u65cf\u53f2\uff0c\u60a3\u8005\u76f4\u7cfb\u4eb2\u5c5e\u60a3\u75c5\u7684\u51e0\u7387\u4e3a\u5bf9\u7167\u7ec4\u768410-40\u500d\uff1b25%-31%\u7684\u5355\u5375\u53cc\u751f\u5b50\u5171\u60a3\u53d1\u4f5c\u6027\u7761\u75c5\uff0c\u63d0\u793a\u9057\u4f20\u56e0\u7d20\u5728\u5176\u8d77\u75c5\u4e2d\u6709\u91cd\u8981\u4f5c\u7528\u3002HLA\u7b49\u4f4d\u57fa\u56e0DQB1*0602\u5728\u53d1\u4f5c\u6027\u7761\u75c5\u60a3\u8005\u4e2d\u6709\u5f88\u9ad8\u7684\u9633\u6027\u7387\uff0c\u8fbe88%-100%\u3002
\u8fd1\u5e74\u6765\uff0c\u98df\u6b32\u7d20\uff08orexin\uff09\u4e0e\u53d1\u4f5c\u6027\u7761\u75c5\u7684\u5173\u7cfb\u4ee4\u4eba\u77a9\u76ee\uff0corexin\u662f\u4e0b\u4e18\u8111\u795e\u7ecf\u5143\u7ec6\u80de\u4ea7\u751f\u7684\u795e\u7ecf\u80bd\uff0c\u5728\u534f\u8c03\u7761\u7720-\u89c9\u9192\u5468\u671f\u65b9\u9762\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u5df2\u77e5\u6709orexin-A\u548corexin-B\u4e24\u79cd\uff0c\u4ee5orexin-B\u4e0e\u672c\u75c5\u7684\u5173\u7cfb\u5bc6\u5207\u3002\u6709\u5b9e\u9a8c\u8868\u660e\uff0corexin\u57fa\u56e0\u7f3a\u5931\u5c0f\u9f20\u51fa\u73b0\u53d1\u4f5c\u6027\u7761\u75c5\u6837\u7761\u7720\u969c\u788d\u3002Nishino\u7b49\u8bc1\u5b9e\uff0c\u53d1\u4f5c\u6027\u7761\u75c5\u60a3\u8005\u8111\u810a\u6db2orexin\u542b\u91cf\u663e\u8457\u504f\u4f4e\uff0c\u4e3a\u8111\u5185orexin\u7f3a\u4e4f\u53d1\u751f\u53d1\u4f5c\u6027\u7761\u75c5\u56e0\u679c\u5173\u7cfb\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002\u5728\u53d1\u4f5c\u6027\u7761\u75c5\u60a3\u8005\u6b7b\u540e\u8111\u7ec4\u7ec7\u5185\uff0c\u53d1\u73b0\u4ea7\u751forexin\u7684\u795e\u7ecf\u5143\u6548\u91cf\u660e\u663e\u51cf\u5c11\uff0c\u63d0\u793a\u4ea7\u751forexin\u7684\u795e\u7ecf\u5143\u6570\u91cf\u7684\u51cf\u5c11\u4e0e\u53d1\u4f5c\u6027\u7761\u75c5\u5bc6\u5207\u76f8\u5173\u3002
\u53d1\u4f5c\u6027\u7761\u75c5\u7684\u55dc\u7761\u662f\u56e0orexin \u795e\u7ecf\u5143\u4f20\u4eba\u4e2d\u8111\u80cc\u4fa7\u7f1d\u9645\u6838\u548c\u84dd\u6591\u7684\u6fc0\u6d3b\u4fe1\u53f7\u51cf\u5c11\uff0e\u4f7f\u8111\u6865\u88ab\u76d6\u80cc\u5916\u4fa7\u90e8\u548c\u811a\u6838\u533a\uff08LDT / PPT \uff09\u5185\u4fc3\u89c9\u9192\u795e\u7ecf\u5143\u6d3b\u52a8\u51cf\u5f31\uff0c\u4fc3\u53d1\u5f02\u5e38\u5feb\u901f\u773c\u52a8\u7761\u7720\u7684\u795e\u7ecf\u5143\u6291\u5236\u51cf\u8f7b\uff0c\u4f7f\u5f02\u5e38\u5feb\u901f\u773c\u52a8\u671f\u63d0\u65e9\u6216\u5728\u4e0d\u9002\u5f53\u7684\u72b6\u51b5\u4e0b\u51fa\u73b0\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7531\u4e8eorexin \u795e\u7ecf\u5143\u4f20\u81f3\u5355\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u6fc0\u6d3b\u4fe1\u53f7\u51cf\u5c11\uff0c\u4f7f\u540e\u8005\u5bf9\u4e0b\u4e18\u8111\u8179\u5916\u4fa7\u89c6\u524d\u533a\uff08VLPO\uff09\u795e\u7ecf\u5143\u7684\u6291\u5236\u51cf\u8f7b\uff0c\u5728\u4e0d\u8be5\u51fa\u73b0\u7684\u60c5\u51b5\u4e0b\u51fa\u73b0\u975e\u5feb\u901f\u773c\u52a8\u7761\u7720\uff0c\u4f34\u89c9\u9192\u5ea6\u964d\u4f4e\u3002
Peyron \u7b49\u53d1\u73b0\uff0c\u4ea7\u751f\u9ed1\u8272\u7d20\u805a\u96c6\u7d20\uff08MCH \uff09\u7684\u795e\u7ecf\u5143\u5206\u5e03\u4e8e\u4e0b\u4e18\u8111\u5916\u4fa7\u90e8\u4e2d\uff0c\u4e0e\u4ea7\u751forexin\u7684\u795e\u7ecf\u5143\u7d27\u5bc6\u6df7\u5408\u5728\u4e00\u8d77\uff0c\u4e24\u8005\u4e4b\u95f4\u65e0\u91cd\u53e0\u3002\u7ed3\u5408\u53d1\u4f5c\u6027\u7761\u75c5\u4e0e\u7279\u5b9a\u7684\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u7b49\u4f4d\u57fa\u56e0\u5f3a\u70c8\u5173\u8054\u6027\uff0cSiebold \u7b49\u63a8\u6d4b\u53d1\u4f5c\u6027\u7761\u75c5\u7684\u53d1\u751f\u4e0e\u4e0b\u4e18\u8111orexin \u795e\u7ecf\u5143\u53d7\u5230\u4e0eDQBI * 0602 \u9650\u5236\u6027T \u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u653b\u51fb\u6709\u5173\u3002
\u7efc\u4e0a\u6240\u8ff0\uff0c\u53d1\u4f5c\u6027\u7761\u75c5\u662f\u4e00\u79cd\u5177\u6709\u9057\u4f20\u6613\u611f\u6027\u3001\u53d7\u5230\u73af\u5883\u56e0\u7d20\u5f71\u54cd\u6216\u89e6\u53d1\u7684\u75be\u75c5\u3002\u53d1\u75c5\u673a\u5236\u4e0e\u7761\u7720\u7ed3\u6784\u7684\u529f\u80fd\u6539\u53d8\u548c\u795e\u7ecf\u9012\u8d28\u529f\u80fd\u5f02\u5e38\u6709\u5173\u3002\u8fd8\u4e0eDQBI * 0602 \u9650\u5236\u6027T\u7ec6\u80de\u4ecb\u5bfc\u7684\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u5bf9\u4e0b\u4e18\u8111\u4ea7\u751forexin \u7684\u795e\u7ecf\u5143\u7684\u7834\u574f\u6709\u5173\u3002\u7ee7\u53d1\u6027\u6216\u75c7\u72b6\u4ec1\u53d1\u4f5c\u6027\u7761\u75c5\u591a\u89c1\u4e8e\u8111\u5916\u4f24\u540e\u3001\u8111\u5e72\u7684\u5176\u4ed6\u80bf\u7624\u3001\u4e0b\u4e18\u8111\u7684\u8089\u82bd\u80bf\u7b49
1、发作性睡病与人类白细胞抗原具有高度相关性，这导致了许多猜测，发作性睡病是一种自身免疫性疾病。
2、发作性睡病是环境因素和遗传因素相互作用的结果，甲型流感病毒感染、疫苗接种、链球菌感染均可增加发作性睡病的风险。
3、有研究报道杀虫剂和除草剂与发作性睡病有关，亦有报道头部肿瘤、卒中与发作性睡病有关，可能是影响了下丘脑分泌素水平
绛旓細鍙戜綔鎬х潯鐥呭紩璧风殑鍘熷洜鏈:1.鏈夊彲鑳芥槸鍥犱负閬椾紶鍘熷洜寮曡捣鐨,鐖舵瘝涓浠ｅ氨鏈夎繖绉嶇柧鐥,涔熸湁鍙兘浼氬奖鍝嶄笅涓浠ｃ2.鏈夊彲鑳芥槸鍥犱负鐜瀵艰嚧鐫,骞虫椂缁忓父鐢熸椿鍦ㄤ竴浜涙伓鍔ｇ殑鐜涓,浼氬紩鍙戣繖绉嶇柧鐥呫3.杩樻湁鍙兘鏄洜涓鑴戦儴鍙楄繃鏌愮鍒涗激寮曞彂鍙戜綔鎬х潯鐥銆4.涔熸湁鍙兘鏄韩浣撳唴鐨勬煇浜涘櫒瀹樼梾鍙,瀵艰嚧鍙戜綔鎬х潯鐥呫傚彂浣滄х潯鐥呯洰鍓嶅湪涓村簥涓婃槸涓...
绛旓細瀵瑰け鐪犳湁蹇ц檻鎴栨亹鎯у績鐞嗘槸褰㈡垚鏈棁鐨勮嚧鐥呭績鐞嗗洜绱銆傚彲缁у彂浜韬綋鍥犵礌銆佺幆澧冨洜绱犮佺缁忕簿绁炵柧鐥呯瓑銆傜劍铏戞亹鎯с佺潯鐪犱笉娣便佹槗鎯婇啋銆佹棭閱掔瓑鐥囩姸銆
绛旓細1銆佸厤鐤郴缁熷姛鑳介殰纰嶅鑷銆傚彂浣滄х潯鐥呭拰鐧界粏鑳炴姉鍘熸湁寰堥珮鐨勭浉鍏虫э紝鎵浠ュ緢澶氬尰瀛︿笓瀹剁寽娴嬶紝鍙戜綔鎬х潯鐥呮湁鍙兘鏄竴绉嶈嚜韬厤鐤х柧鐥咃紝涓庤嚜韬厤鐤郴缁熷姛鑳介殰纰嶆湁鍏崇郴銆2銆鎮ｆ湁鍏朵粬鐥呮瘨鎬х柧鐥呮垨鑰呮帴瑙︾梾姣閮戒細澧炲姞鎮ｄ笂鍙戜綔鎬х潯鐥呯殑姒傜巼銆傚洜涓鸿繖绉嶇梾鏄鍦ㄧ幆澧冨拰閬椾紶鍥犵礌鍏卞悓璧蜂綔鐢ㄧ殑缁撴灉锛屾墍浠ユ劅鏌撶敳鍨嬫祦鎰熺梾姣掋...
绛旓細鍙戜綔鎬х潯鐥呭紩璧风殑鍘熷洜銆鏈夊彲鑳芥槸鍥犱负閬椾紶鍘熷洜寮曡捣鐨锛岀埗姣嶄竴浠ｅ氨鏈夎繖绉嶇柧鐥咃紝涔熸湁鍙兘浼氬奖鍝嶄笅涓浠ｃ傛湁鍙兘鏄洜涓虹幆澧冨鑷寸潃锛屽钩鏃剁粡甯哥敓娲诲湪涓浜涙伓鍔ｇ殑鐜涓紝浼氬紩鍙戣繖绉嶇柧鐥呫傝繕鏈夊彲鑳芥槸鍥犱负鑴戦儴鍙楄繃鏌愮鍒涗激寮曞彂鍙戜綔鎬х潯鐥鍙戜綔鎬х潯鐥呮槸涓绉嶅叿鏈夐仐浼犳э紝鏄撴劅鎬э紝鍙楀埌鐜鍥犵礌褰卞搷鑰岃Е鍙戠殑涓绉嶇柧鐥呫傜柧鐥...
绛旓細鍙戜綔鎬х潯鐥呮槸涓绉嶅師鍥犱笉鏄庣殑鎱㈡х潯鐪犻殰纰锛屽畠鐨勪富瑕佷复搴婅〃鐜版槸鐧藉ぉ鍙嶅鍙戜綔鐨勬棤娉曢亸鍒剁殑鐫＄湢锛岀対鍊掑彂浣滃拰澶滈棿鍑虹幇鐫＄湢闅滅銆傚彂浣滄х潯鐥呯殑鐥呭洜鐩墠璁や负鏈変互涓嬪嚑涓洜绱狅紝绗竴锛屼笅涓樿剳澶栦晶鍖哄垎娉岀礌绁炵粡鍏冪壒寮傛т抚澶憋細涔熸槸鍙戜綔鎬х潯鐥呯殑鐗瑰緛鎬х殑鐥呯悊鏀瑰彉銆傜浜岋紝鍩哄洜鐨勬槗鎮ｆс傜涓夛紝鐜鍥犵礌銆傜鍥涳紝涓庡厤鐤...
绛旓細涓銆閬椾紶鎬у師鍥狅細鍙戜綔鎬х潯鐥呭拰閬椾紶鏈夌潃涓瀹氱殑鑱旂郴锛屽鏋滅洿绯讳翰灞炰腑鏈変汉鎮ｆ湁杩欎釜鐤剧梾锛岄偅涔堝叾鍚庝唬鎮ｇ梾鐨勫嚑鐜囬潪甯搁珮锛屽彲鑳戒細寮曡捣涓嶅悓绋嬪害鐨勭潯鐪犻殰纰嶏紝瀵艰嚧鎮ｈ呯櫧澶╃獊鐒堕棿鍡滅潯锛屽鑷存偅鑰呭嚭鐜颁笉鍙姉鎷掔殑鐭椂闂村唴鍏ョ潯鐨勭幇璞°備簩銆佺幆澧冨洜绱狅細杩欎釜鐤剧梾鍜岀幆澧冩湁鐫涓瀹氱殑鑱旂郴锛屾湁鐨勪汉濡傛灉鎯呯华杩囧害绱у紶鎴栬呴暱鏃堕棿杩囧害...
绛旓細鍙戜綔鎬х潯鐥呮槸涓绉嶅師鍥犱笉鏄庣殑鎱㈡х潯鐪犻殰纰锛屽叾鐥呭洜灏氭湭鏄庣‘銆備竴鑸涓烘槸澶氱鐜鍥犵礌涓閬椾紶鍥犵礌鐩镐簰浣滅敤鐨勭粨鏋溿1鍨嬪彂浣滄х潯鐥呬笌涓嬩笜鑴戝垎娉岀礌-1鍒嗘硨缂哄け鎴栦笉瓒虫湁鍏筹紝2鍨嬪彂浣滄х潯鐥呯殑鍘熷洜灏氭湭鏄庣‘銆傛煇浜涚柧鐥咃紝濡傝偪鐦ゃ佸奖鍝嶄笅涓樿剳鐨勮绠℃х柧鐥呫佸ご閮ㄥ垱浼ゃ佸笗閲戞．鐥呫佸绯荤粺钀庣缉绛夛紝涔熷彲寮曡捣鍙戜綔鎬х潯鐥呫傚熀...
绛旓細杩欐槸涓绉嶇幇鍦ㄥ勾杞讳汉寰堝鏄撳緱鐨勭柧鐥咃紝涔熸槸鍥犱负绀句細鐨勪竴绉嶆櫘閬嶇幇璞★紝鐥呭洜灏辨槸鐜板湪寰堝鐨勪汉鍘嬪姏闈炲父澶э紝鑰屼笖浣滄伅涔熸槸闈炲父鐨勪笉瑙勫緥锛屾墠瀵艰嚧浜嗚繖绉鐤剧梾鐨勪骇鐢锛屽緢澶氫汉鍦ㄨ繖鏂归潰涔熸槸琛ㄧず闈炲父鐨勪笉鐞嗚В銆
绛旓細鍙戜綔鎬х潯鐥锛坣arcolepsy锛夋槸涓绉嶅師鍥犱笉鏄庣殑鎱㈡х潯鐪犻殰纰嶏紝涓村簥涓婁互涓嶅彲鎶楁嫆鐨勭煭鏈鐫＄湢鍙戜綔涓虹壒鐐癸紝澶氫簬鍎跨鎴栭潚骞存湡璧风梾銆傚線寰浼存湁鐚濆掑彂浣溿佺潯鐪犵槴鐥棁銆佺潯鐪犲够瑙夌瓑鍏朵粬鐥囩姸锛屽悎绉颁负鍙戜綔鎬х潯鐥呭洓鑱旂棁銆傚彂鐥呮満鍒跺皻鏈竻妤氾紝鍙兘涓庤剳骞茬綉鐘剁粨鏋勪笂琛屾縺娲荤郴缁熷姛鑳介檷浣庢垨妗ヨ剳灏句晶缃戠姸鏍稿姛鑳戒孩杩涙湁鍏炽傜梾鍥犵洰鍓嶆湭鏄...
绛旓細鍙戜綔鎬х潯鐥鏄竴绉嶇櫧澶╀笉鍙姉鎷掔殑鐭湡鍙戜綔鐫 鐪狅紝 浼寸対鍊掋 鐫＄湢鐦棯銆 鍏ョ潯鍓嶅够瑙変负涓昏鐥囩姸锛 閮 鍒嗘偅鑰呬即鏈夊闂寸潯鐪犵磰涔辩殑涓绉嶇潯鐪闅滅鎬х柧鐥锛 鏄缁忕郴缁熺殑鐤戦毦鐥呫 鍎跨鑷宠佸勾鍧囧彲鍙戠梾锛 10-25 宀佽捣鐥呰呭眳澶 [1-2] 銆 鍏剁梾鍥犱笉鏄庯紝 澶氳涓烘湁閬椾紶鏄撴劅 鍊惧悜锛 姝ゅ锛 鎰熸煋銆 鎯呯华銆 ...
