请问目前主要使用治疗类风湿性关节炎的生物药剂有哪几种？ 本人生物化学本科内科学学术硕士考不了执业医师
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目前用于治疗RA的生物制剂有三种:英夫利西单抗（类克）、依那西普和阿达木单抗,在临床治疗中发现,一些患者最初使用这些药物治疗是有效的,但在治疗一段时间后会出现疗效消失,称为“继发治疗失败”,出现这种现象的原因目前还不清楚。临床发现对一种抗TNFα治疗无效的患者在更换为另一种后,仍然会有效。这些患者在更换为类克注射3次后,随访1年X-线改良Sharp评分进展就可以降低50%,注射类克30周后,一年的X-线进展率几乎为0。该研究结果显示,依那西普治疗失败的患者在改为类克联合MTX治疗后,仍然能够获益。因此说，类克在治疗类风湿性关节炎方面，效果还是比较突出的。绛旓細锛1锛夐潪婵绱犳ф姉鐐庤嵂鐗 杩欑被鑽墿閫氬父绉颁竴绾胯嵂鐗┿備富瑕侀氳繃鎶戝埗鍓嶅垪鑵虹礌鐨勫悎鎴愯揪鍒版秷鐐庛佹鐥涗綔鐢ㄣ傚彟澶栵紝杩欑被鑽墿灏氬彲鎶戝埗纾烽吀浜岄叝閰朵娇缁嗚優鍐呯殑cAMP 澧炲姞锛屾憾閰朵綋鑶滅ǔ瀹氭у鍔狅紝鍑忓皯閰剁殑閲婃斁銆備絾杩欑被鑽墿铏界劧鑳藉噺杞荤棁鐘讹紝鍗村寮曡捣绫婚婀挎у叧鑺傜値鐨勫厤鐤弽搴斾笉鍙戠敓鏍规湰褰卞搷锛屽洜姝や笉鑳芥帶鍒剁梾鎯呭彂灞曪紝鍙兘鏀瑰杽...
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绛旓細娌荤枟绫婚婀挎鍏宠妭鐐庣殑绛栫暐涓昏闆嗕腑鍦ㄦ帶鍒剁値鐥囧拰缂撹В鐥囩姸锛屽悓鏃剁淮鎶ゅ叧鑺傚姛鑳藉拰棰勯槻鐣稿舰銆備互涓嬫槸甯哥敤鐨勬不鐤楁柟娉曪細涓鑸枟娉曪細瀵逛簬鍙戠儹鍜屽叧鑺傝偪鐥涚殑鎮ｈ咃紝鍒濆闃舵搴斿崸搴婁紤鎭紝鐥囩姸缂撹В鍚庨愭笎澧炲姞娲诲姩閲忥紝闃叉鍏宠妭鍍电‖銆傞ギ椋熶腑瑕佷繚璇佽泲鐧借川鍜岀淮鐢熺礌鐨勫厖瓒筹紝涓ラ噸璐鑰呭彲閫傚綋杈撹銆傚鏈夋墎妗冧綋鐐庣瓑鎱㈡х梾鐏讹紝鍙湪韬綋...
绛旓細鎵嬫湳娌荤枟绫婚婀挎鍏宠妭鐐庡彲浠ヨ捣鍒扮珛绔胯褰辩殑鏁堟灉,浣嗘槸杩欑娌荤枟鏂瑰紡鐥涜嫤姣旇緝鐨勫ぇ,鑰屼笖鎭㈠璧锋潵姣旇緝鐨勬參,鎵浠ヤ竴瀹氳鎱庨噸鐨浣跨敤,鎵嬫湳娌荤枟绫婚婀挎у叧鑺傜値鐨勬柟娉涓昏鏈:婊戣啘鍒囬櫎鏈:涓昏鐢ㄤ簬鎺屾寚鍏宠妭銆佽厱鍏宠妭鍙婅啙鍏宠妭绛,鍙鐥呭彉鐨勬粦鑶滆繘琛屽垏闄ゃ傚叧鑺傚啿娲+闀滀笅婊戣啘鍒囬櫎鏈:鍦ㄥぇ鍏宠妭,灏ゅ叾鏄啙鍏宠妭,鍙互鍦ㄥ叧鑺傞暅...
绛旓細銆愪富娌汇绫婚婀挎鍏宠妭鐐庛傚睘婀跨儹涓轰富,椋庡瘨涓哄吋,瀵掔儹铏氬疄閿欐潅,姘旇娴侀氫笉鐣呯殑鐑椆璇佽呫 銆愭柟瑙ｃ戞柟涓綋褰掑吇琛娲昏,鍠勬鑲岃倝銆佸叧鑺傘佺缁忕棝;榛勮姪娓呯儹鐕ユ箍;鐢樿崏璋冨拰璇歌嵂,缂撴ユ鐥;闃查鏁ｉ瀵掓箍鐥广佽В鐑晣鐥,娌讳竴韬敖鐥;闃插繁鑻﹀瘨娉勭儹;娴锋鐨椋庢箍,閫氱粡缁,娑堣偪姝㈢棝;杩炵繕鍗囨诞瀹ｆ暎,娴侀氭皵琛,娉勮缁忕粶涔嬬儹;钖忚嫛浠...
