张辰宇的学术研究 张辰宇的张辰宇介绍
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一、近五年来承担的学术研究课题
1. 2型糖尿病的发生发展分子机制的研究。国家科技部“973”项目，2006-2011年，首席科学家。
2. 2型糖尿病临床干细胞应用的研究。国家科技部“863”项目，2006 -2011年，首席科学家。
3. 内分泌学与代谢病。国家自然科学基金杰出青年基金，2003-2006年，项目负责人。
二、近五年来发表的学术论文 代表性文章：
1. Krauss S, Zhang CY, Lowell BB. The Mitochondrial Uncoupling Protein Homologues. Nature Reviews Molecular Cell Biology, 6(3):248-61, 2005.
2. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell, 123(3):493-505,2005.
3. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metabolism, 3(6):417-27, 2006.
4. Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature, 449(7159):228-32, 2007.
5. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature Medicine, 14(2):144-53, 2008.
回国后发表的文章：
*1. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY.Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008 Oct;18(10):997-1006.
*2. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010 Jul 9;39(1):133-44.
*3. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q, Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K, Zhang CY. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2012 Jan;22(1):107-26.
*4. Chen X, Gao C, Li H, Huang L, Sun Q, Dong Y, Tian C, Gao S, Dong H, Guan D, Hu X, Zhao S, Li L, Zhu L, Yan Q, Zhang J, Zen K, Zhang CY. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. 2010 Oct;20(10):1128-37.
*5. Wang C, Yang C, Chen X, Yao B, Yang C, Zhu C, Li L, Wang J, Li X, Shao Y, Liu Y, Ji J, Zhang J, Zen K, Zhang CY, Zhang C. Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clin Chem. 2011 Dec;57(12):1722-31.
*6. Hu Z, Chen X, Zhao Y, Tian T, Jin G, Shu Y, Chen Y, Xu L, Zen K, Zhang CY, Shen H. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol. 2010 Apr 1;28(10):1721-6.
*7. Li LM, Hu Z, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY, Zen K. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res. 2010 Dec 1;70(23):9798-807.
*8. Zen K, Zhang CY. Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. Epub 2010 Nov 9.
*9. Chen X, Liang H, Zhang J, Zen K, Zhang CY. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. Trends Cell Biol. Epub 2012 Jan 17.
*10. Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y, Cai X, Wang K, Wang G, Ba Y, Zhu L, Wang J, Yang R, Zhang Y, Ren Z, Zen K, Zhang J, Zhang CY. Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene. 2009 Mar 12;28(10):1385-92.
11. Chen X, Liang H, Zhang J, Zen K, Zhang CY. Horizontal transfer of microRNAs: molecular mechanisms and clinical applications.Protein Cell. 2012 Jan;3(1):28-37.
12. Liu R, Chen X, Du Y, Yao W, Shen L, Wang C, Hu Z, Zhuang R, Ning G, Zhang C, Yuan Y, Li Z, Zen K, Ba Y, Zhang CY. Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer. Clin Chem. Clin Chem. Epub 2011 Dec 22.
13. Chen X, Hu Z, Wang W, Ba Y, Ma L, Zhang C, Wang C, Ren Z, Zhao Y, Wu S, Zhuang R, Zhang Y, Hu H, Liu C, Xu L, Wang J, Shen H, Zhang J, Zen K, Zhang CY. Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis.Int J Cancer. 2012 Apr 1;130(7):1620-8.
14. Wang K, Li P, Dong Y, Cai X, Hou D, Guo J, Yin Y, Zhang Y, Li J, Liang H, Yu B, Chen J, Zen K, Zhang J, Zhang CY, Chen X. A microarray-based approach identifies ADP ribosylation factor-like protein 2 as a target of microRNA-16. J Biol Chem. J Biol Chem. 2011 Mar 18;286(11):9468-76.
15. Liu R, Zhang C, Hu Z, Li G, Wang C, Yang C, Huang D, Chen X, Zhang H, Zhuang R, Deng T, Liu H, Yin J, Wang S, Zen K, Ba Y, Zhang CY. A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis.Eur J Cancer. 2011 Mar;47(5):784-91.
16. Xie L, Wang T, Yu S, Chen X, Wang L, Qian X, Yu L, Ding Y,Zhang CY, Liu B. Cell-free miR-24 and miR-30d, potential diagnostic biomarkers in malignant effusions.Clin Biochem. 2011 Feb;44(2-3):216-20.
17. Zhang C, Wang C, Chen X, Yang C, Li K, Wang J, Dai J, Hu Z, Zhou X, Chen L, Zhang Y, Li Y, Qiu H, Xing J, Liang Z, Ren B, Yang C, Zen K, Zhang CY. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem. 2010 Dec;56(12):1871-9.
18. Xie L, Chen X, Wang L, Qian X, Wang T, Wei J, Yu L, Ding Y, Zhang CY, Liu B. Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions. BMC Cancer. 2010 Oct 28;10:591.
19. Guo J, Dong Q, Fang Z, Chen X, Lu H, Wang K, Yin Y, Cai X, Zhao N, Chen J, Zen K, Zhang J, Zhang CY. Identification of miRNAs that are associated with tumor metastasis in neuroblastoma. Cancer Biol Ther. 2010 Mar;9(6): 446-52.
20. Chen X, Li Q, Wang J, Guo X, Jiang X, Ren Z, Weng C, Sun G, Wang X, Liu Y, Ma L, Chen JY, Wang J, Zen K, Zhang J,Zhang CY. Identification and characterization of novel amphioxus microRNAs by Solexa sequencing. Genome Biol. 2009;10(7):R78.
21. Li S, Chen X, Zhang H, Liang X, Xiang Y, Yu C, Zen K, Li Y, Zhang CY. Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res. 2009 Sep;50(9):1756-65.
22. Chen X, Wang K, Chen J, Guo J, Yin Y, Cai X, Guo X, Wang G, Yang R, Zhu L, Zhang Y, Wang J, Xiang Y, Weng C, Zen K, Zhang J, Zhang CY. In vitro evidence suggests that miR-133a-mediated regulation of uncoupling protein 2 (UCP2) is an indispensable step in myogenic differentiation. J Biol Chem. 2009 Feb 20;284(8):5362-9.
23. Zhang H, Li J, Liang X, Luo Y, Zen K, Zhang CY. Uncoupling Protein 2 Negatively Regulates Glucose-Induced Glucagon-Like Peptide-1 (GLP-1) Secretion. J Mol Endocrinol. 2012 Jan 18.
24. Xu W, Guo T, Zhang Y, Jiang X, Zhang Y, Zen K, Yu B, Zhang CY. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression. Exp Cell Res. 2011 May 1;317(8):1083-92.
25. Gu Z, Li J, Gao S, Gong M, Wang J, Xu H, Zhang CY, Wang J. InterMitoBase: an annotated database and analysis platform of protein-protein interactions for human mitochondria. BMC Genomics. 2011 Jun 30;12:335.
26. Gong M, Li J, Wang M, Wang J, Zen K, Zhang CY. The evolutionary trajectory of mitochondrial carrier family during metazoan evolution. BMC Evol Biol. 2010 Sep 16;10:282.
27. Xu W, Hou D, Jiang X, Lu Z, Guo T, Liu Y, Wang D, Zen K, Yu B, Zhang CY. The protective role of peroxisome proliferator-activated receptor γ coactivator-1α in hyperthyroid cardiac hypertrophy.J Cell Physiol. 2011 Nov 21. doi: 10.1002/jcp.24015.
28. Zhang D, Shen M, Mikita A, Zhang W, Liu Y, Liu Q, Dai Y,Zhang CY, Zheng S, Zheng XX. Targeting Uncoupling Protein-2 Improves Islet Graft Function. Cell Transplant.2011;20(3):421-9.
29. Sun LB, Zhang Y, Wang Q, Zhang H, Xu W, Zhang J, Xiang J, Li QG, Xiang Y, Wang DJ, Zhang CY. Serum palmitic acid-oleic acid ratio and the risk of coronary artery disease: a case-control study. J Nutr Biochem. 2011 Apr;22(4):311-7.
30. Chen K, Sun G, Lv Z, Wang C, Jiang X, Li D, Zhang CY. Molecular cloning of amphioxus uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system. Biochem Biophys Res Commun. 2010 Oct 1;400(4):701-6.
31. Yang J, Li JH, Wang J,Zhang CY. Molecular modeling of BAD complex resided in a mitochondrion integrating glycolysis and apoptosis. J Theor Biol. 2010 Sep 21;266(2):231-41.
32. Zhu L, Wang Q, Zhang L, Fang Z, Zhao F, Lv Z, Gu Z, Zhang J, Wang J, Zen K, Xiang Y, Wang D, Zhang CY. Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients. Cell Res. 2010 Jun;20(6):676-87.
33. Jiang X, Zhang Y, Hou D, Zhu L, Xu W, Ding L, Qi X, Sun G, Liu C, Zhang J, Zen K, Xiang Y, Zhang CY. 17beta-estradiol inhibits oleic acid-induced rat VSMC proliferation and migration by restoring PGC-1alpha expression. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):74-80.
34. Wang C, Sun G, Chen K, Lv Z, Peng S, Jiang X, Xiang Y,Zhang CY. Molecular cloning of lamprey uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system. Mitochondrion. 2010 Jan;10(1):54-61.
35. Zhu L, Sun G, Zhang H, Zhang Y, Chen X, Jiang X, Jiang X, Krauss S, Zhang J, Xiang Y, Zhang CY. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One. 2009;4(1):e4182.
36. Qu A, Jiang C, Xu M, Zhang Y, Zhu Y, Xu Q, Zhang CY, Wang X. PGC-1alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery. Am J Physiol Cell Physiol. 2009 Sep;297(3):C645-53.
37. Luo Y, Zhu W, Jia J, Zhang CY, Xu Y. NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury. J Mol Neurosci. 2009 Sep;39(1-2):262-8.
38. Jin X, Yang YD, Chen K, Lv ZY, Zheng L, Liu YP, Chen SH, Yu CH, Jiang XY, Zhang CY, Li YM. HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H2O2 levels: a novel mechanism for NAFLD. J Hepatol. 2009 May;50(5):1019-28.
39. Zhang Y, Liu C, Zhu L, Jiang X, Chen X, Qi X, Liang X, Jin S, Zhang P, Li Q, Wang D, Liu X, Zeng K, Zhang J, Xiang Y, Zhang CY. PGC-1alpha inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells. PLoS One. 2007 Nov 7;2(11):e1137.
40. Zhang Y, Ba Y, Liu C, Sun G, Ding L, Gao S, Hao J, Yu Z, Zhang J, Zen K, Tong Z, Xiang Y, Zhang CY. PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res. 2007 Apr;17(4):363-73.
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